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Invitrogen
SCIN Polyclonal Antibody
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Product Details
PA5-55034
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SCIN. Recombinant protein control fragment (Product #RP-92602).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RNLASITRIV EVDVDANSLN SNDVFVLKLP QNSGYIWVGK GASQEEEKGA EYVASVLKCK TLRIQEGEEP EEFWNSLGGK KDYQTSPLLE TQAEDHPPRL YGCSNK
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 90%.
Target Information
The SCIN gene, also known as scinderin, encodes for a calcium-dependent actin filament-severing protein that is involved in the regulation of the cytoskeleton. It plays a significant role in actin filament dynamics, influencing cellular processes such as cell shape, motility, secretion, and division. SCIN has been identified as a novel oncogene, with its abnormal expression strongly correlated to various cancers, including glioma and uterine corpus endometrial carcinoma. Specific mutations like S673F and S381Y in SCIN are linked with poor prognosis and are potential targets for cancer diagnosis, prognosis, and treatment strategies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adseverin; Scinderin; unnamed protein product
Gene Aliases: KIAA1905; SCIN
UniProt ID: (Human) Q9Y6U3
Entrez Gene ID: (Human) 85477
central nervous system development
actin polymerization or depolymerization
negative regulation of cell proliferation
calcium ion regulated exocytosis
cell projection assembly
regulation of chondrocyte differentiation
positive regulation of apoptotic process
actin nucleation
positive regulation of megakaryocyte differentiation
actin filament severing
barbed-end actin filament capping
positive regulation of secretion
positive regulation of actin nucleation
actin filament capping
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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