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Invitrogen
SCLY Polyclonal Antibody
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FIGURE: 1 / 1
SCLY Antibody (PA5-79958) in WB
Western blot analysis of SCLY in Lane 1: U87 cell lysate, Lane 2: HeLa cell lysate, Lane 3: 293T cell lysate, Lane 4: MCF-7 cell lysate, Lane 5: COLO320 cell lysate, Lane 6: HE1080 cell lysate. Sample was incubated with SCLY polyclonal antibody (Product # PA5-79958).
Product Details
PA5-79958
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human SCLY (432-445aa QDLKQAVAQLEDQA).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: U87 Cell, HELA Cell, 293T Cell, MCF-7 Cell, COLO320 Cell, HE1080 Cell.
Target Information
The SCLY gene encodes selenocysteine lyase, an enzyme involved in selenium metabolism, which plays a critical role in the recycling of selenocysteine from selenoproteins. SCLY catalyzes the conversion of selenocysteine into alanine, releasing selenium for reuse in the biosynthesis of new selenoproteins. It is chiefly active in the liver and kidneys, contributing to maintaining selenium homeostasis, which is vital for numerous biological functions due to selenium's role in antioxidant defense and thyroid hormone metabolism. Alterations in SCLY function or expression can affect selenium levels in the body and are associated with disorders related to oxidative stress and metabolic imbalances. Given the importance of selenium in cellular protection and immune function, SCLY is also of interest in studies focusing on dietary supplementation and disease prevention strategies, particularly in conditions like cancer and cardiovascular diseases where oxidative damage is prevalent.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hSCL; Selenocysteine lyase; unnamed protein product
Gene Aliases: hSCL; SCL; SCLY
UniProt ID: (Human) Q96I15
Entrez Gene ID: (Human) 51540
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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