This antibody is predicted to react with bovine, rat and rabbit based on sequence homology.
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: GEFSP1; sodium channel beta-1 subunit; Sodium channel subunit beta-1; sodium channel, voltage gated, type I beta subunit; sodium channel, voltage-gated, type I, beta; sodium channel, voltage-gated, type I, beta polypeptide
Gene Aliases: ATFB13; BRGDA5; GEFSP1; SCN1B