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Invitrogen
SCN2A Polyclonal Antibody
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Product Details
PA5-36545
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 1002-1052 of human Na+ CP type II alpha
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons. The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternative product; Brain Type II; HBSC II; RIIA sodium channel protein; Sodium channel protein brain II subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type II subunit alpha; sodium channel protein, brain II subunit alpha; sodium channel protein, brain type 2 alpha subunit; sodium channel voltage-gated type II alpha polypeptide; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type II, alpha 1; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha polypeptide 1; sodium channel, voltage-gated, type II, alpha subunit; unnamed protein product; voltage-gated sodium channel subtype II; Voltage-gated sodium channel subunit alpha Nav1.2; voltage-gated sodium channel type II alpha subunit
Gene Aliases: 6430408L10; A230052E19Rik; BFIC3; BFIS3; BFNIS; DEE11; EA9; EIEE11; HBA; HBSCI; HBSCII; Na(v)1.2; NAC2; NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN; SCN2A; SCN2A1; SCN2A2; ScpII
UniProt ID: (Human) Q99250, (Rat) P04775, (Mouse) B1AWN6
Entrez Gene ID: (Human) 6326, (Rat) 24766, (Mouse) 110876
action potential
ion transport
sodium ion transport
nervous system development
memory
intrinsic apoptotic signaling pathway in response to osmotic stress
neuronal action potential
ion transmembrane transport
sodium ion transmembrane transport
myelination
neuron apoptotic process
transmembrane transport
cellular response to hypoxia
cardiac muscle cell action potential involved in contraction
regulation of ion transmembrane transport
membrane depolarization during action potential
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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