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Invitrogen
SCN2B Polyclonal Antibody
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FIGURE: 1 / 2
SCN2B Antibody (PA5-101892) in ICC/IF
Immunocytochemistry analysis of SCN2B in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with SCN2B polyclonal antibody (Product # PA5-101892) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-101892
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SCN2B(Accession O60939), corresponding to amino acid residues Q70-E120.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SCN2B.
Target Information
Scn2b is a member of voltage-gated sodium channels (NaV) that are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. Scn2b are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Scn2b is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. In Scn2b, the subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Also, Scn2b interacts with TNR (Tenascin R-precursor) and may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. The protein encoded by the Scn2b gene is the beta 2 subunit of the type II voltage-gated sodium channel. Scn2b protein is involved in cell-cell adhesion and cell migration. Defects in the Scn2b gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. Diseases associated with SCN2B include Atrial Fibrillation, Familial, 14 and Scn2b-Related Familial Atrial Fibrillation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: neuronal voltage-gated sodium channel beta 2 subunit; Sodium channel beta 2; Sodium channel regulatory subunit beta-2; sodium channel subunit beta-2; sodium channel, voltage gated, type II beta subunit; sodium channel, voltage-gated, type II, beta polypeptide; unnamed protein product
Gene Aliases: 2810451E09Rik; AI840361; ATFB14; Gm183; SCN2B; SCNB2; UNQ326/PRO386
UniProt ID: (Human) O60939, (Rat) P54900, (Mouse) Q56A07
Entrez Gene ID: (Human) 6327, (Rat) 25349, (Mouse) 72821
voltage-gated sodium channel activity
sodium channel regulator activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
protein binding
voltage-gated ion channel activity
sodium channel activity
myelin protein
ion transport
sodium ion transport
chemical synaptic transmission
nervous system development
response to heat
gene expression
positive regulation of sodium ion transport
sodium ion transmembrane transport
response to pyrethroid
cardiac muscle contraction
regulation of atrial cardiac muscle cell membrane depolarization
cardiac conduction
cardiac muscle cell action potential involved in contraction
membrane depolarization during action potential
membrane depolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
membrane repolarization during ventricular cardiac muscle cell action potential
regulation of sodium ion transmembrane transporter activity
transport
regulation of ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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