Search
Invitrogen
SCN2B Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-76248
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein of human SCN2B.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Scn2b is a member of voltage-gated sodium channels (NaV) that are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. Scn2b are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Scn2b is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. In Scn2b, the subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Also, Scn2b interacts with TNR (Tenascin R-precursor) and may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. The protein encoded by the Scn2b gene is the beta 2 subunit of the type II voltage-gated sodium channel. Scn2b protein is involved in cell-cell adhesion and cell migration. Defects in the Scn2b gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. Diseases associated with SCN2B include Atrial Fibrillation, Familial, 14 and Scn2b-Related Familial Atrial Fibrillation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: neuronal voltage-gated sodium channel beta 2 subunit; Sodium channel regulatory subunit beta-2; sodium channel, voltage gated, type II beta subunit; sodium channel, voltage-gated, type II, beta polypeptide; unnamed protein product
Gene Aliases: ATFB14; SCN2B; UNQ326/PRO386
UniProt ID: (Human) O60939
Entrez Gene ID: (Human) 6327
ion transport
sodium ion transport
chemical synaptic transmission
nervous system development
response to heat
gene expression
positive regulation of sodium ion transport
sodium ion transmembrane transport
response to pyrethroid
cardiac muscle contraction
regulation of atrial cardiac muscle cell membrane depolarization
cardiac conduction
cardiac muscle cell action potential involved in contraction
membrane depolarization during action potential
membrane depolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
membrane repolarization during ventricular cardiac muscle cell action potential
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support