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Invitrogen
SCN8A Polyclonal Antibody
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FIGURE: 1 / 5
SCN8A Antibody (PA5-37276) in ICC/IF
Immunofluorescence analysis of SCN8A was performed using 70% confluent log phase IMR-32 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with SCN8A Polyclonal Antibody (Product # PA5-37276) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then with Goat anti-Rabbit IgG (Heavy Chain), Superclonal™ Recombinant Secondary Antibody, Alexa Fluor 488 conjugate (Product #... View More
Product Details
PA5-37276
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in human Na+ CP type VIII alpha
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 225 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The sodium channel protein type 8 subunit alpha (Na+ CP type VIII alpha ) is a multi-pass, transmembrane protein that mediates the sodium ion permeability of excitable membranes. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming alpha subunit, a noncovalently associated beta1 subunit and a disulfide-linked beta2 subunit. The two beta subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons. Sodium channels are important for rapid signal transduction but also play a significant role in neuronal development. Defects of the SCN8A gene have exhibited detrimental effects on the growth of secondary motoneurons. Loss of SCN8A expression will result in progressive paralysis and early death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ataxia 3; hNa6/Scn8a voltage-gated sodium channel; Na+ channel; NaCh6; Peripheral nerve protein type 4; PN4; Scn8a (PN4); Sodium channel 6; Sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII subunit alpha; sodium channel voltage-gated type VIII alpha polypeptide; sodium channel, voltage gated, type VIII alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage-gated, type 8, alpha polypeptide; sodium channel, voltage-gated, type 8, alpha subunit; sodium channel, voltage-gated, type VIII, alpha polypeptide; Voltage-gated sodium channel subunit alpha Nav1.6; voltage-gated sodium channel type VIII alpha protein
Gene Aliases: AI853486; C630029C19Rik; CERIII; CIAT; dmu; EIEE13; MED; mnd-2; mnd2; NaCh6; Nav1.6; Nbna1; nmf2; nmf335; nmf58; nur14; PN4; SCN8A; seal
UniProt ID: (Human) Q9UQD0, (Mouse) Q9WTU3, (Rat) O88420
Entrez Gene ID: (Human) 6334, (Mouse) 20273, (Rat) 29710
sodium ion transport
nervous system development
peripheral nervous system development
neuronal action potential
regulation of ion transmembrane transport
sodium ion transmembrane transport
myelination
regulation of postsynaptic membrane potential
membrane depolarization during action potential
transport
ion transport
muscle organ development
sensory perception of sound
locomotory behavior
adult walking behavior
adult locomotory behavior
response to toxic substance
neuromuscular process
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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