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OriGene
SCNN1A Polyclonal Antibody
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FIGURE: 1 / 1
SCNN1A Antibody (TA890149) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SCNN1A (RC228555, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SCNN1. Positive lysates LY422000 (100 µg) and LC422000 (20 µg) can be purchased separately from OriGene.
Product Details
TA890149
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein of human SCNN1A
Conjugate
Form
Liquid
Concentration
1.93 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Epithelial sodium channels are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel's syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha ENaC-2; Alpha-ENaC; Alpha-NaCH; amiloride-sensitive epithelial sodium channel alpha subunit; Amiloride-sensitive sodium channel subunit alpha; amiloride-sensitive sodium channel subunit alpha 2; ENaC subunit alpha; epithelial Na(+) channel subunit alpha; Epithelial sodium channel subunit alpha; FLJ21883; nasal ENaC; hnENac; nasal epithelial sodium channel alpha subunit; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; sodium channel epithelial 1 alpha subunit; Sodium channel epithelial 1 subunit alpha; sodium channel, non voltage gated 1 alpha subunit; sodium channel, non-voltage-gated 1 alpha; sodium channel, nonvoltage-gated 1 alpha; unnamed protein product
Gene Aliases: BESC2; ENaCa; ENaCalpha; LIDLS3; PHA1B1; SCNEA; SCNN1; SCNN1A
UniProt ID: (Human) P37088
Entrez Gene ID: (Human) 6337
ion transport
sodium ion transport
cellular sodium ion homeostasis
regulation of blood pressure
ion transmembrane transport
sodium ion transmembrane transport
multicellular organismal water homeostasis
sensory perception of salty taste
sensory perception of sour taste
sodium ion homeostasis
cellular response to acidic pH
sodium ion import across plasma membrane
cellular response to aldosterone
cellular response to vasopressin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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