Proteintech

SCP3 Polyclonal Antibody

SCP3 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 7

SCP3 Antibody (23024-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HepG2 cells using 23024-1-AP (SCP3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SCP3 Antibody in Immunoprecipitation (IP)

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Product Details

23024-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

1:50-1:500

View 11 publications 11 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SCP3 Fusion Protein Ag19330 (13-236 aa encoded by BC062662)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GKPSVEDQF TRAYDFETED KKDLSGSEED VIEGKTAVIE KRRKKRSSAG VVEDMGGEVQ NMLEGVGVDI NKALLAKRKR LEMYTKASLK TSNQKIEHVW KTQQDQRQKL NQEYSQQFLT LFQQWDLDMQ KAEEQEEKIL NMFRQQQKIL QQSRIVQSQR LKTIKQLYEQ FIKSMEELEK NHDNLLTGAQ NEFKKEMAML QKKIMMETQQ QEIASVRKSL QSMLF (13-236 aa encoded by B C062662)

Target Information

This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Transcriptome Analysis in High Temperature Inhibiting Spermatogonial Stem Cell Differentiation In Vitro.

Reproductive sciences (Thousand Oaks, Calif.)

Gao WJ,Li HX,Feng J,Lu XR,Yin PL,Jia H,Ma WZ

Thu Jun 01 00:00:00 UTC 2023

Exposure to elevated temperature affects the expression of PIWI-interacting RNAs and associated transcripts in mouse testes.

Andrology

Chen W,Zhao Z,Cen S,Lv D,Wu J,Zhou X,Yang T,Zhao T,Hou L,Mao X

Mon May 01 00:00:00 UTC 2023

Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice.

Nature communications

Jiang X,Cheng Y,Zhu Y,Xu C,Li Q,Xing X,Li W,Zou J,Meng L,Azhar M,Cao Y,Tong X,Qin W,Zhu X,Bao J

Thu Jun 22 00:00:00 UTC 2023

Systematic assessment of hexavalent chromium-induced damage to male fertility and the preventive role of melatonin: a longitudinal study from the translational point of view.

Molecular human reproduction

Li T,Lv Y,Wu Z,Guo M,Liu R,Zeng W,Zheng Y

Fri Jun 30 00:00:00 UTC 2023

Chromodomain helicase DNA-binding domain 2 maintains spermatogonial self-renewal by promoting chromatin accessibility and mRNA stability.

iScience

Min Z,Xin H,Liu X,Wan J,Fan Z,Rao X,Fan J,Yang L,Li D

Thu Dec 22 00:00:00 UTC 2022

Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.

International journal of nanomedicine

Fu Y,Yuan P,Zheng Y,Wei Y,Gao L,Ruan Y,Chen Y,Li P,Feng W,Zheng X

Tue Apr 12 00:00:00 UTC 2022

Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.

International journal of nanomedicine

Fu Y,Yuan P,Zheng Y,Wei Y,Gao L,Ruan Y,Chen Y,Li P,Feng W,Zheng X

Tue Apr 12 00:00:00 UTC 2022

Optimized protocol for isolation of germ cells from mouse testis by centrifugal elutriation.

STAR protocols

Cao Y,Meng L,Cheng Y,Azhar M,Jiang X,Xing X,Bao J

Fri Sep 16 00:00:00 UTC 2022

SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.

Nucleic acids research

Guan Y,Lin H,Leu NA,Ruthel G,Fuchs SY,Busino L,Luo M,Wang PJ

Fri May 20 00:00:00 UTC 2022

SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.

Nucleic acids research

Guan Y,Lin H,Leu NA,Ruthel G,Fuchs SY,Busino L,Luo M,Wang PJ

Fri May 20 00:00:00 UTC 2022

Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Fu Y,Yuan P,Zheng Y,Gao L,Wei Y,Chen Y,Li P,Ruan Y,Zheng X,Feng W

Wed Jun 01 00:00:00 UTC 2022

Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse.

Cellular and molecular life sciences : CMLS

Li H,Chen H,Zhang X,Qi Y,Wang B,Cui Y,Ren J,Zhao Y,Chen Y,Zhu T,Wang Y,Yao L,Guo Y,Zhu H,Li Y,Situ C,Guo X

Fri Aug 05 00:00:00 UTC 2022

YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis.

Cell reports

Liu R,Kasowitz SD,Homolka D,Leu NA,Shaked JT,Ruthel G,Jain D,Lin H,Keeney S,Luo M,Pillai RS,Wang PJ

Tue Dec 14 00:00:00 UTC 2021

Melatonin protects the mouse testis against heat-induced damage.

Molecular human reproduction

Zhang P,Zheng Y,Lv Y,Li F,Su L,Qin Y,Zeng W

Sat Feb 29 00:00:00 UTC 2020

Melatonin protects the mouse testis against heat-induced damage.

Molecular human reproduction

Zhang P,Zheng Y,Lv Y,Li F,Su L,Qin Y,Zeng W

Sat Feb 29 00:00:00 UTC 2020

The testis-specifically expressed gene Trim69 is not essential for fertility in mice.

Journal of biomedical research

He X,Xie W,Li H,Cui Y,Wang Y,Guo X,Sha J

Fri Aug 21 00:00:00 UTC 2020

NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis.

Cell death and differentiation

Zhang B,Tang Z,Li L,Lu LY

Wed Jul 01 00:00:00 UTC 2020

The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†.

Biology of reproduction

Serra N,Velte EK,Niedenberger BA,Kirsanov O,Geyer CB

Fri Feb 01 00:00:00 UTC 2019

The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†.

Biology of reproduction

Serra N,Velte EK,Niedenberger BA,Kirsanov O,Geyer CB

Fri Feb 01 00:00:00 UTC 2019

Control of homologous recombination by the HROB-MCM8-MCM9 pathway.

Genes & development

Hustedt N,Saito Y,Zimmermann M,Álvarez-Quilón A,Setiaputra D,Adam S,McEwan A,Yuan JY,Olivieri M,Zhao Y,Kanemaki MT,Jurisicova A,Durocher D

Tue Oct 01 00:00:00 UTC 2019

Abnormal synapses, recombination, and impaired double-strand break repair in a man with nonobstructive azoospermia.

Asian journal of andrology

Luo XY,Yang QL,Xin H,Zhao FF,Bai R,Li FY,Zhu J,Sun YP

Tue Aug 20 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: SCP-3; Synaptonemal complex protein 3; synaptonemal complex protein 3-like

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Gene Aliases: COR1; RNASCP3; RPRGL4; SCP3; SPGF4; SYCP3

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UniProt ID: (Human) Q8IZU3, (Rat) Q63520, (Mouse) P70281

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Entrez Gene ID: (Human) 50511, (Rat) 25561, (Mouse) 20962

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Function(s)

DNA binding protein heterodimerization activity protein binding

Process(es)

meiotic DNA repair synthesis female meiosis sister chromatid cohesion mitotic nuclear division meiotic nuclear division synapsis synaptonemal complex assembly spermatogenesis female meiosis chromosome segregation sperm chromatin condensation spermatogenesis, exchange of chromosomal proteins negative regulation of apoptotic process chiasma assembly cell division meiotic cell cycle lateral element assembly male meiosis I cell cycle spermatid development female meiosis chromosome separation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SCP3 Polyclonal Antibody

SCP3 Antibody (23024-1-AP) in ICC/IF

Product Details

23024-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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