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SCRAPPER Polyclonal Antibody
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FIGURE: 1 / 2
SCRAPPER Antibody (600-401-EE4) in IHC (P)
Immunohistochemistry of SCRAPPER antibody. Tissue: Human brain tissue. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: SCRAPPER antibody at 2.5 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: SCRAPPER is nuclear and occasionally cytoplasmic. Staining: SCRAPPER as a precipitated red signa... View More
Product Details
600-401-EE4
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-SCRAPPER antibody was prepared from whole rabbit serum produced by repeated immunizations with a 18 amino acid synthetic peptide near the C-terminus of the human SCRAPPER.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: F-box and leucine-rich repeat protein 20; F-box protein FBL2; F-box/LRR-repeat protein 2-like; F-box/LRR-repeat protein 20; FBXL20b; scrapper; unnamed protein product
Gene Aliases: 2610511F20Rik; 4632423N09Rik; AI849362; AL117906; C86145; FBL2; Fbl20; Fbxl2; FBXL20; mKIAA4147; Scr
UniProt ID: (Human) Q96IG2, (Mouse) Q9CZV8
Entrez Gene ID: (Human) 84961, (Rat) 64039, (Mouse) 72194
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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