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Proteintech
SCUBE3 Polyclonal Antibody
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Product Details
16773-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SCUBE3 Fusion Protein Ag10085 (643-992 aa encoded by BC052263)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YYHGQTEQC VPCPAGTFQE REGQLSCDLC PGSDAHGPLG ATNVTTCAGQ CPPGQHSVDG FKPCQPCPRG TYQPEAGRTL CFPCGGGLTT KHEGAISFQD CDTKVQCSPG HYYNTSIHRC IRCAMGSYQP DFRQNFCSRC PGNTSTDFDG STSVAQCKNR QCGGELGEFT GYIESPNYPG NYPAGVECIW NINPPPKRKI LIVVPEIFLP SEDECGDVLV MRKNSSPSSI TTYETCQTYE RPIAFTARSR KLWINFKTSE ANSARGFQIP YVTYDEDYEQ LVEDIVRDGR LYASENHQEI LKDKKLIKAF FEVLAHPQNY FKYTEKHKEM LPKSFIKLLR SKVSSFLRPY K (643-992 aa encoded by BC052263)
Target Information
SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart. Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth. SCUBE3 has been shown to be an endogenous TGF-Beta receptor ligand and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-Beta receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-Beta1, VEGF, Snail, and Slug.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CEGF3; CUB domain and EGF-like repeat containing 3; SCUBE3; signal peptide; signal peptide, CUB and EGF-like domain containing protein 3; Signal peptide, CUB and EGF-like domain-containing protein 3; unnamed protein product
Gene Aliases: CEGF3; D030038I21Rik; SCUBE3; SSFSC2
UniProt ID: (Human) Q8IX30, (Mouse) Q66PY1
Entrez Gene ID: (Human) 222663, (Rat) 294297, (Mouse) 268935
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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