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Invitrogen
SCXA Polyclonal Antibody
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FIGURE: 1 / 8
SCXA Antibody (PA5-23943) in IHC (P)
Immunohistochemistry analysis of SCXA in paraffin-embedded Human breast carcinoma tissue. Samples were incubated with SCXA polyclonal antibody (Product # PA5-23943) using a dilution of 1:100 for 1 hour at room temperature followed by undiluted CRF Anti-Polyvalent HRP Polymer antibody. Tissue was fixed with formaldehyde at room temperature. Heat induced epitope retrieval was performed by EDTA buffer (pH 9 0)... View More
Product Details
PA5-23943
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Chicken,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 172-201 amino acids from the C-terminal region of human SCXA
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Amount
64 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with chicken based on sequence homology.
Target Information
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and bHLH transcription factor binding activity. Contributes to E-box binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Basic helix-loop-helix transcription factor scleraxis; bHLHa41; bHLHa48; Class A basic helix-loop-helix protein 41; Class A basic helix-loop-helix protein 48; class II bHLH protein scleraxis; scleraxis basic helix-loop-helix transcription factor; scleraxis homolog A; scleraxis homolog B
Gene Aliases: BB114693; BHLHA41; BHLHA48; Scl; SCX; SCXA; SCXB
UniProt ID: (Human) Q7RTU7, (Mouse) Q64124
Entrez Gene ID: (Human) 642658, (Mouse) 20289
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
bHLH transcription factor binding
sequence-specific DNA binding
protein dimerization activity
E-box binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
protein heterodimerization activity
basic helix-loop-helix transcription factor
mesoderm formation
tissue homeostasis
endochondral ossification
chondrocyte differentiation
heart valve morphogenesis
heart valve formation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
cell differentiation
collagen fibril organization
BMP signaling pathway
developmental process
positive regulation of collagen biosynthetic process
skeletal muscle cell differentiation
tendon development
tendon cell differentiation
tendon formation
deltoid tuberosity development
negative regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system development
Sertoli cell differentiation
Sertoli cell development
face morphogenesis
regulation of cartilage development
positive regulation of cartilage development
sclerotome development
cellular response to mechanical stimulus
cellular response to cAMP
cellular response to follicle-stimulating hormone stimulus
cellular response to transforming growth factor beta stimulus
cellular response to BMP stimulus
positive regulation of gastrulation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
cartilage development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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