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Product Details
PA5-56690
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SDE2. Recombinant protein control fragment (Product #RP-94304).
Conjugate
Form
Liquid
Concentration
2.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2647049
Product Specific Information
Immunogen sequence: ETQEKKAESK EPIEEEPTGA GLNKDKETEE RTDGERVAEV APEERENVAV AKLQESQPGN AVIDKETIDL LAFTSVAELE LLGLEKLKCE LMA^M
^M
Highest antigen sequence identity to the following orthologs: Mouse - 37%, Rat - 40%.
Target Information
Involved in both DNA replication and cell cycle control (PubMed:27906959). Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner (PubMed:27906959). Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S-phase progression (PubMed:27906959). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ35382; Replication stress response regulator SDE2; Splicing regulator SDE2; UPF0667 protein C1orf55
Gene Aliases: C1orf55; dJ671D7.1; SDE2
UniProt ID: (Human) Q6IQ49
Entrez Gene ID: (Human) 163859
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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