|Tested species reactivity||Human, Mouse, Pig|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide made to an C-terminal region of the human SDHA protein (within residues 500-664).|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 50% glycerol, 0.1% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The target sequence has 94% sequence homology with rat and 93% sequence homology with porcine.
SDHA is an important component in the citric acid cycle and respiratory chain. SDHA converts succinate to fumarate, transfers electrons in the respiratory chain, and ultimately transfers electrons to ubiquinone. SDHA is localized within the mitochondrial inner membrane. Mutations in the gene have been associated with Leigh syndrome and Huntington's disease. However, SDHA also appears to have tumor suppressor effects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.