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Proteintech
SDHB Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-10620
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SDHB fusion protein Ag0968
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MAAVVALSL RRRLPATTLG GACLQASRGA QTAAATAPRI KKFAIYRWDP DKAGDKPHMQ TYEVDLNKCG PMVLDALIKI KNEVDSTLTF RRSCREGICG SCAMNINGGN TLACTRRIDT NLNKVSKIYP LPHMYVIKDL VPDLSNFYAQ YKSIEPYLKK KDESQEGKQQ YLQSIEEREK LDGLYECILC ACCSTSCPSY WWNGDKYLGP AVLMQAYRWM IDSRDDFTEE RLAKLQDPFS LYRCHTIMNC TRTCPKGLNP GKAIAEIKKM MATYKEKKAS V
Target Information
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ92337; Ip; iron-sulfur subunit; Iron-sulfur subunit of complex II; Malate dehydrogenase [quinone] iron-sulfur subunit; OTTHUMP00000044624; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex subunit B; succinate dehydrogenase complex, subunit B, iron sulfur (Ip); succinate-ubiquinone oxidoreductase Ip subunit precursor; unnamed protein product
Gene Aliases: 0710008N11Rik; CWS2; IP; MC2DN4; PGL4; PPGL4; SDH; SDH1; SDH2; SDHB; SDHIP
UniProt ID: (Human) P21912, (Mouse) Q9CQA3, (Rat) P21913
Entrez Gene ID: (Human) 6390, (Mouse) 67680, (Rat) 298596
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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