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SEC14L1 may play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation. May also regulate the SLC18A3 and SLC5A7 cholinergic transporters.
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Protein Aliases: SEC14-like protein 1
Gene Aliases: PRELID4A; SEC14L; SEC14L1
UniProt ID: (Human) Q92503
Entrez Gene ID: (Human) 6397