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Invitrogen
SEC61A1 Polyclonal Antibody
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Product Details
PA5-88175
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 310-420 of human SEC61A1 (NP_0374681)
Conjugate
Form
Liquid
Concentration
0.98 mg/mL
Amount
98 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ARFSGNLLVS LLGTWSDTSS GGPARAYPVG GLCYYLSPPE SFGSVLEDPV HAVVYIVFML GSCAFFSKTW IEVSGSSAKD VAKQLKEQQM VMRGHRETSM VHELNRYIPT A; Positive Samples: A-549; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein
Target Information
The Sec61 complex is responsible for translocation of proteins across the rough endoplasmic reticulum membrane. Sec61 is composed of three subunits: alpha, beta, and gamma; that associate to form a heterotrimer. Multiple heterotrimers associate forming the ER translocon. Sec61 alpha is a polytopic protein that has ten membrane-spanning loops. Sec61 has been found to be tightly associated with membrane bound ribosomes, either directly or through adaptor proteins, and is required for assembly of membrane and secretory proteins.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: protein transport protein SEC61 alpha subunit; protein transport protein Sec61 subunit alpha; Protein transport protein Sec61 subunit alpha isoform 1; Sec61 alpha 1 subunit; Sec61 alpha subunit homolog; Sec61 alpha-1; sec61 homolog; SEC61 translocon alpha 1 subunit; SEC61, alpha subunit; transport protein sec61 alpha subunit; unnamed protein product
Gene Aliases: AA408394; AA410007; ADTKD5; CVID15; HNFJ4; HSEC61; SEC61; SEC61A; SEC61A1
UniProt ID: (Human) P61619, (Mouse) P61620, (Rat) P61621
Entrez Gene ID: (Human) 29927, (Mouse) 53421, (Rat) 80843
cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane, translocation
posttranslational protein targeting to membrane
endoplasmic reticulum organization
protein transport
posttranslational protein targeting to membrane, translocation
response to interferon-gamma
pronephric nephron development
protein targeting to ER
protein insertion into ER membrane
calcium ion transmembrane transport
transport
cell growth
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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