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Proteintech
SEC61B Polyclonal Antibody
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Product Details
15087-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SEC61B Fusion Protein Ag7169 (1-96 aa encoded by BC001734)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Amount
22.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPGPTPSGT NVGSSGRSPS KAVAARAAGS TVRQRKNASC GTRSAGRTTS AGTGGMWRFY TEDSPGLKVG PVPVLVMSLL FIASVFMLHI WGKYTRS (1-96 aa encoded by B C001734)
Target Information
The Sec61 complex is responsible for translocation of proteins across the rough endoplasmic reticulum membrane. Sec61 is composed of three subunits: alpha, beta, and gamma; that associate to form a heterotrimer. Multiple heterotrimers associate forming the ER translocon. Sec61 alpha is a polytopic protein that has ten membrane-spanning loops. Sec61 has been found to be tightly associated with membrane bound ribosomes, either directly or through adaptor proteins, and is required for assembly of membrane and secretory proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: protein translocation complex beta; protein transport protein SEC61 beta subunit; Protein transport protein Sec61 subunit beta; sec61 beta; Sec61 beta subunit; Sec61 complex, beta subunit; SEC61 translocon beta subunit; SEC61B
Gene Aliases: 1190006C12Rik; AI326121; AW122942; SEC61B
UniProt ID: (Human) P60468, (Mouse) Q9CQS8
Entrez Gene ID: (Human) 10952, (Mouse) 66212, (Rat) 298068
SRP-dependent cotranslational protein targeting to membrane, translocation
intracellular protein transport
protein transport
retrograde protein transport, ER to cytosol
posttranslational protein targeting to membrane, translocation
ERAD pathway
protein import into nucleus, translocation
transport
ER-associated ubiquitin-dependent protein catabolic process
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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