Search
Rockland
SELK Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
600-401-EG6
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-SELK antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid synthetic peptide near the C-terminus of human SELK.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: heat shock protein; heat shock protein, 30 kDa; Selenoprotein K; SelK; unnamed protein product
Gene Aliases: 1110001C03Rik; AA673253; Hsp30; HSPC030; HSPC297; SELENOK; SELK
UniProt ID: (Human) Q9Y6D0, (Mouse) Q9JLJ1, (Rat) P59798
Entrez Gene ID: (Human) 58515, (Mouse) 80795, (Rat) 290549
positive regulation of defense response to virus by host
ion transport
calcium ion transport
response to oxidative stress
macrophage derived foam cell differentiation
protein palmitoylation
endoplasmic reticulum calcium ion homeostasis
positive regulation of chemokine production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
T cell proliferation
positive regulation of T cell proliferation
respiratory burst after phagocytosis
regulation of calcium-mediated signaling
regulation of protein transport
establishment of localization in cell
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
positive regulation of monocyte chemotactic protein-1 production
T cell migration
positive regulation of neutrophil migration
neutrophil migration
positive regulation of T cell migration
transport
positive regulation of cell migration
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support