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Proteintech
SELS Polyclonal Antibody
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Product Details
15591-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SELS Fusion Protein Ag7928 (1-189 aa encoded by BC005840)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MERQEESLS ARPALETEGL RFLHTTVGSL LATYGWYIVF SCILLYVVFQ KLSARLRALR QRQLDRAAAA VEPDVVVKRQ EALAAARLKM QEELNAQVEK HKEKLKQLEE EKRRQKIEMW DSMQEGKSYK GNAKKPQEED SPGPSTSSVL KRKSDRKPLR GGGYNPLSGE GGGACSWRPG RRGPSSGGUG (1-189 aa encoded by BC005840)
Target Information
This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. It participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: histocompatibility 47; MGC104346; MGC2553; Minor histocompatibility antigen H47; Selenoprotein S; SelS; Sg2; Tanis; valosin-containing protein-interacting membrane protein; VCP-interacting membrane protein; VCP-interacting membrane selenoprotein
Gene Aliases: 1500011E07Rik; AD-015; ADO15; C78786; H-4; H-47; H4; H47; SBBI8; SELENOS; SELS; SEPS1; sg2; VIMP
UniProt ID: (Human) Q9BQE4, (Rat) Q8VHV8, (Mouse) Q9BCZ4
Entrez Gene ID: (Human) 55829, (Rat) 286900, (Mouse) 109815
negative regulation of acute inflammatory response to antigenic stimulus
ER overload response
response to glucose
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
retrograde protein transport, ER to cytosol
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
cellular response to oxidative stress
cell redox homeostasis
negative regulation of nitric-oxide synthase biosynthetic process
response to redox state
cellular response to lipopolysaccharide
regulation of nitric oxide metabolic process
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of macrophage apoptotic process
intracellular protein transport
negative regulation of inflammatory response
regulation of gluconeogenesis
cellular response to insulin stimulus
establishment of protein localization
negative regulation of glycogen biosynthetic process
negative regulation of glucose import
cellular oxidant detoxification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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