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Proteintech
SEMA3C Polyclonal Antibody
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Product Details
19242-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SEMA3C Fusion Protein Ag5480 (34-380 aa encoded by BC030690)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Amount
33 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DELRETKTS EYFSLSHHPL DYRILLMDED QDRIYVGSKD HILSLNINNI SQEALSVFWP ASTIKVEECK MAGKDPTHGC GNFVRVIQTF NRTHLYVCGS GAFSPVCTYL NRGRRSEDQV FMIDSKCESG KGRCSFNPNV NTVSVMINEE LFSGMYIDFM GTDAAIFRSL TKRNAVRTDQ HNSKWLSEPM FVDAHVIPDG TDPNDAKVYF FFKEKLTDNN RSTKQIHSMI ARICPNDTGG LRSLVNKWTT FLKARLVCSV TDEDGPETHF DELEDVFLLE TDNPRTTLVY GIFTTSSSVF KGSAVCVYHL SDIQTVFNGP FAHKEGPNHQ LISYQGRIPY PRPGTCPG (34-380 aa encoded by BC030690 )
Target Information
The SEMA3C gene encodes the protein semaphorin 3C, a member of the semaphorin family known for its roles in axonal guidance, cellular signaling, and vascular development. Semaphorin 3C is involved in guiding neurons during development by serving as a repulsive cue, helping establish proper neural network formation through interaction with neuropilin and plexin receptors. It also plays crucial roles in angiogenesis and cardiac development by influencing endothelial cell behavior and migration. In the context of cancer, SEMA3C is implicated in tumor progression, where its dysregulation can promote tumor cell invasion and metastasis by modifying the extracellular matrix and affecting cellular adhesion. Research has demonstrated that SEMA3C can alter the tumor microenvironment, making it a potential target for cancer therapies aimed at inhibiting metastasis and controlling tumor growth. Understanding SEMA3C's function in various biological processes continues, highlighting its significance in developmental biology and disease modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Sema E; semaphorin E; Semaphorin-3C; Semaphorin-E; unnamed protein product
Gene Aliases: 1110036B02Rik; SEMA3C; SEMAE; SemE
UniProt ID: (Human) Q99985, (Mouse) Q62181
Entrez Gene ID: (Human) 10512, (Mouse) 20348
neural crest cell migration
somitogenesis
blood vessel remodeling
outflow tract septum morphogenesis
outflow tract morphogenesis
cardiac right ventricle morphogenesis
pulmonary myocardium development
immune response
nervous system development
axon guidance
heart development
response to xenobiotic stimulus
post-embryonic development
neural tube development
cell differentiation
positive regulation of cell migration
negative chemotaxis
limb bud formation
dichotomous subdivision of terminal units involved in salivary gland branching
semaphorin-plexin signaling pathway
cardiac endothelial to mesenchymal transition
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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