Immunogen sequence: QDRVDFGQTE PHTVLFHEPG SSSVWVGGRG KVYLFDFPEG KNASVRTVNI GSTKGSCLDK RDCENYITLL ERRSEGLLAC GTNARHPSCW NLVNGTVVPL GEMRGYAPFS PDENSLVLFE GD
CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes through its receptors - plexin C1 and beta1 integrins.
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Protein Aliases: CD108; CDw108; H-Sema-L; JMH blood group antigen; John Milton Hagen blood group H-Sema K1; John-Milton-Hargen human blood group Ag; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group); sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A; Sema K1; Sema L; SEMAL; semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group); Semaphorin-7A; Semaphorin-K1; Semaphorin-L
Gene Aliases: CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; SEMA7A; SEMAK1; SEMAL
UniProt ID: (Human) O75326
Entrez Gene ID: (Human) 8482