SENP1 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SENP deconjugates SUMO1 from HIPK2 and from HDAC1, which decreases the transcriptional repression activity of the latter.
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Protein Aliases: SEN1; Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SUMO1/sentrin specific protease 1
Gene Aliases: SENP1; SuPr-2
UniProt ID: (Human) Q9P0U3
Entrez Gene ID: (Human) 29843
Molecular Function: protease