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Invitrogen
SENP1 Polyclonal Antibody
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FIGURE: 1 / 4
SENP1 Antibody (PA5-88971) in IHC (P)
Immunohistochemistry analysis of SENP1 in paraffin-embedded human liver cancer. Samples were incubated with SENP1 Polyclonal antibody (Product # PA5-88971) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-88971
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 220-420 of human SENP1 (NP_0012545231)
Conjugate
Form
Liquid
Concentration
2.32 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SRCLSSSKNT LKDSLFKNGN SCASQIIGSD TSSSGSASIL TNQEQLSHSV YSLSSYTPDV AFGSKDSGTL HHPHHHHSVP HQPDNLAASN TQSEGSDSVI LLKVKDSQTP TPSSTFFQAE LWIKELTSVY DSRARERLRQ IEEQKALALQ LQNQRLQERE HSVHDSVELH LRVPLEKEIP VTVVQETQKK GHKLTDSEDE F; Positive Samples: BxPC-3, HT-29, HepG2, HeLa, Mouse testis, Mouse thymus, Rat testis; Cellular Location: Cytoplasm, Nucleus
Target Information
SENP1 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SENP deconjugates SUMO1 from HIPK2 and from HDAC1, which decreases the transcriptional repression activity of the latter.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SEN1; Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SUMO-1 protease 2; SUMO1/sentrin specific peptidase 1; SUMO1/sentrin specific protease 1; Sumo1/sentrin/SMT3 specific peptidase 1; SuPr-2
Gene Aliases: 2310046A20Rik; D15Ertd528e; E330036L07Rik; SENP1; SuPr-2; Supr2
UniProt ID: (Human) Q9P0U3, (Mouse) P59110
Entrez Gene ID: (Human) 29843, (Mouse) 223870, (Rat) 300193
proteolysis
activation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of definitive erythrocyte differentiation
protein sumoylation
protein desumoylation
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of transcription from RNA polymerase II promoter
apoptotic signaling pathway
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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