Search Thermo Fisher Scientific
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Immunogen sequence: SRCLSSSKNT LKDSLFKNGN SCASQIIGSD TSSSGSASIL TNQEQLSHSV YSLSSYTPDV AFGSKDSGTL HHPHHHHSVP HQPDNLAASN TQSEGSDSVI LLKVKDSQTP TPSSTFFQAE LWIKELTSVY DSRARERLRQ IEEQKALALQ LQNQRLQERE HSVHDSVELH LRVPLEKEIP VTVVQETQKK GHKLTDSEDE F; Positive Samples: BxPC-3, HT-29, HepG2, HeLa, Mouse testis, Mouse thymus, Rat testis; Cellular Location: Cytoplasm, Nucleus
SENP1 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SENP deconjugates SUMO1 from HIPK2 and from HDAC1, which decreases the transcriptional repression activity of the latter.
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Protein Aliases: SEN1; Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SUMO-1 protease 2; SUMO1/sentrin specific peptidase 1; SUMO1/sentrin specific protease 1; Sumo1/sentrin/SMT3 specific peptidase 1; SuPr-2
Gene Aliases: 2310046A20Rik; D15Ertd528e; E330036L07Rik; SENP1; SuPr-2; Supr2
UniProt ID: (Human) Q9P0U3, (Mouse) P59110
Entrez Gene ID: (Human) 29843, (Mouse) 223870, (Rat) 300193
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