SUMO is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1, SUMO2, and SUMO3 into the conjugatable mature forms and catalyze the deconjugation of these same SUMO proteins from their targeted substrates. SENP2 may also down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
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Protein Aliases: Axam2; CT; Sentrin-specific protease 2; Sentrin/SUMO-specific protease SENP2; SMT3-specific isopeptidase 2; Smt3ip2; SUMO-1 protease 1; SUMO-1 protease-1; SUMO-1/Smt3-specific isopeptidase 2; SUMO/sentrin specific protease 2; SUMO1/sentrin/SMT3 specific protease 2; SuPr-1
Gene Aliases: 2310007L05Rik; 4930538C18Rik; AI646780; AW554757; AXAM2; KIAA1331; mKIAA1331; SENP2; SMT3IP2; SuPr-1; Supr1
Molecular Function: protease