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Invitrogen
SENP2 Polyclonal Antibody
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FIGURE: 1 / 3
SENP2 Antibody (PA5-11330) in IHC (P)
Immunohistochemistry analysis of SENP2 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with SENP2 polyclonal antibody (Product # PA5-11330) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepa... View More
Product Details
PA5-11330
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 502-533 amino acids from the C-terminal region of human SENP2
Conjugate
Form
Liquid
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
SUMO is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1, SUMO2, and SUMO3 into the conjugatable mature forms and catalyze the deconjugation of these same SUMO proteins from their targeted substrates. SENP2 may also down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Axam2; CT; sentrin (SUMO1) specific peptidase 2; Sentrin-specific protease 2; Sentrin/SUMO-specific protease SENP2; SMT3-specific isopeptidase 2; Smt3ip2; SUMO-1 protease 1; SUMO-1 protease-1; SUMO-1/Smt3-specific isopeptidase 2; SUMO/sentrin specific protease 2; SUMO1/sentrin/SMT3 specific peptidase 2; SUMO1/sentrin/SMT3 specific protease 2; SuPr-1; unnamed protein product
Gene Aliases: 2310007L05Rik; 4930538C18Rik; AI646780; AW554757; AXAM2; KIAA1331; mKIAA1331; SENP2; SMT3IP2; SuPr-1; Supr1
UniProt ID: (Human) Q9HC62, (Mouse) Q91ZX6
Entrez Gene ID: (Human) 59343, (Mouse) 75826
proteolysis
heart development
protein transport
Wnt signaling pathway
protein sumoylation
protein desumoylation
regulation of Wnt signaling pathway
negative regulation of protein ubiquitination
positive regulation of protein ubiquitination
protein destabilization
regulation of DNA endoreduplication
fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
mRNA transport
regulation of macromolecule metabolic process
trophoblast giant cell differentiation
labyrinthine layer development
regulation of primary metabolic process
regulation of G1/S transition of mitotic cell cycle
positive regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
transport
dorsal/ventral axis specification
negative regulation of protein binding
negative regulation of chromatin binding
negative regulation of DNA damage response, signal transduction by p53 class mediator
regulation of protein metabolic process
spongiotrophoblast layer development
negative regulation of signal transduction by p53 class mediator
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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