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SENP2 Antibody (PA5-120603) in WB
Western blot analysis of SENP2 in extracts of various cell line. Samples were incubated with SENP2 Polyclonal antibody (Product # PA5-120603) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-120603
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 366-589 of human SENP2 (NP_067640.2).
Conjugate
Unconjugated
Form
Liquid
Concentration
1.37 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914175
Product Specific Information
Positive test controls include: rat lung, rat testis.
Immunogen sequence: LELTEDMEKE ISNALGHGPQ DEILSSAFKL RITRGDIQTL KNYHWLNDEV INFYMNLLVE RNKKQGYPAL HVFSTFFYPK LKSGGYQAVK RWTKGVNLFE QEIILVPIHR KVHWSLVVID LRKKCLKYLD SMGQKGHRIC EILLQYLQDE SKTKRNSDLN LLEWTHHSMK PHEIPQQLNG SDCGMFTCKY ADYISRDKPI TFTQHQMPLF RKKMVWEILH QQLL
Target Information
SUMO is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1, SUMO2, and SUMO3 into the conjugatable mature forms and catalyze the deconjugation of these same SUMO proteins from their targeted substrates. SENP2 may also down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Axam; Axam2; Axin-associating molecule; CT; Sentrin-specific protease 2; Sentrin/SUMO-specific protease SENP2; Smt3ip2; SUMO-1 protease 1; SUMO-1 protease-1; SUMO-1/Smt3-specific isopeptidase 2; SUMO/sentrin specific peptidase 2; SUMO/sentrin specific protease 2; SuPr-1
Gene Aliases: 2310007L05Rik; 4930538C18Rik; AI646780; AW554757; Axam; mKIAA1331; Senp2; Smt3ip2; SuPr-1; Supr1
UniProt ID: (Mouse) Q91ZX6, (Rat) Q9EQE1
Entrez Gene ID: (Mouse) 75826, (Rat) 78973
positive regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
proteolysis
transport
heart development
dorsal/ventral axis specification
protein transport
Wnt signaling pathway
protein desumoylation
negative regulation of protein ubiquitination
positive regulation of protein ubiquitination
protein destabilization
negative regulation of protein binding
regulation of DNA endoreduplication
negative regulation of chromatin binding
negative regulation of DNA damage response, signal transduction by p53 class mediator
fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
mRNA transport
regulation of protein metabolic process
trophoblast giant cell differentiation
labyrinthine layer development
spongiotrophoblast layer development
negative regulation of signal transduction by p53 class mediator
regulation of G1/S transition of mitotic cell cycle
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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