Proteintech

SENP3 Polyclonal Antibody

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SENP3 Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 17659-1-AP (SENP3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

SENP3 Antibody in Immunoprecipitation (IP) — IP result of anti-SENP3 (IP: 17659-1-AP, 4 µg; Detection: 17659-1-AP 1:500) with Y79 cells lysate 2000 µg.

Product Details

17659-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 5 publications 5 publications

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SENP3 Fusion Protein Ag11911 (225-574 aa encoded by BC080658)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: GLRWTPKSP LDPDSGLLSC TLPNGFGGQS GPEGERSLAP PDASILISNV CSIGDHVAQE LFQGSDLGMA EEAERPGEKA GQHSPLREEH VTCVQSILDE FLQTYGSLIP LSTDEVVEKL EDIFQQEFST PSRKGLVLQL IQSYQRMPGN AMVRGFRVAY KRHVLTMDDL GTLYGQNWLN DQVMNMYGDL VMDTVPEKVH FFNSFFYDKL RTKGYDGVKR WTKNVDIFNK ELLLIPIHLE VHWSLISVDV RRRTITYFDS QRTLNRRCPK HIAKYLQAEA VKKDRLDFHQ GWKGYFKMNV ARQNNDSDCG AFVLQYCKHL ALSQPFSFTQ QDMPKLRRQI YKELCHCKLT V (225-574 aa encoded by BC080658)

Target Information

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Targeting PELP1 oncogenic signaling in TNBC with the small molecule inhibitor SMIP34.

Breast cancer research and treatment

Altwegg KA,Pratap UP,Liu Z,Liu J,Sanchez JR,Yang X,Ebrahimi B,Panneerdoss DM,Li X,Sareddy GR,Viswanadhapalli S,Rao MK,Vadlamudi RK

Sat Jul 01 00:00:00 EDT 2023

SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced neuroinflammation after cerebral ischemia and reperfusion injury.

iScience

Xia Q,Mao M,Zhan G,Luo Z,Zhao Y,Li X

Fri Jun 16 00:00:00 EDT 2023

SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced neuroinflammation after cerebral ischemia and reperfusion injury.

iScience

Xia Q,Mao M,Zhan G,Luo Z,Zhao Y,Li X

Fri Jun 16 00:00:00 EDT 2023

SUMO1 SUMOylates and SENP3 deSUMOylates NLRP3 to orchestrate the inflammasome activation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Shao L,Liu Y,Wang W,Li A,Wan P,Liu W,Shereen MA,Liu F,Zhang W,Tan Q,Wu K,Liu Y,Wu J

Wed Jan 01 00:00:00 EST 2020

SUMO1 SUMOylates and SENP3 deSUMOylates NLRP3 to orchestrate the inflammasome activation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Shao L,Liu Y,Wang W,Li A,Wan P,Liu W,Shereen MA,Liu F,Zhang W,Tan Q,Wu K,Liu Y,Wu J

Wed Jan 01 00:00:00 EST 2020

TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb.

eLife

Ma X,Yang T,Luo Y,Wu L,Jiang Y,Song Z,Pan T,Liu B,Liu G,Liu J,Yu F,He Z,Zhang W,Yang J,Liang L,Guan Y,Zhang X,Li L,Cai W,Tang X,Gao S,Deng K,Zhang H

Thu Jan 17 00:00:00 EST 2019

Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.

Molecular & cellular proteomics : MCP

Fanis P,Gillemans N,Aghajanirefah A,Pourfarzad F,Demmers J,Esteghamat F,Vadlamudi RK,Grosveld F,Philipsen S,van Dijk TB

Thu Nov 01 00:00:00 EDT 2012

Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.

Molecular & cellular proteomics : MCP

Fanis P,Gillemans N,Aghajanirefah A,Pourfarzad F,Demmers J,Esteghamat F,Vadlamudi RK,Grosveld F,Philipsen S,van Dijk TB

Thu Nov 01 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: DKFZP586K0919; DKFZp762A152; Sentrin-specific protease 3; sentrin/SUMO-specific protease 3; Sentrin/SUMO-specific protease SENP3; SUMO-1-specific protease 3; SUMO/sentrin specific peptidase 3; SUMO/sentrin specific protease 3

Gene Aliases: SENP3; SMT3IP1; SSP3; SUSP3; Ulp1

UniProt ID: (Human) Q9H4L4

Entrez Gene ID: (Human) 26168, (Rat) 303245

Molecular Function: protease