The antibody is specific to SENP5.
SUMO (small ubiquitin-related modifier), a member of the ubiquitin-like protein family, regulates diverse cellular functions of a variety of target proteins including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the "GG" region by SUMO-specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin-specific (or SUMO-specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1-3 and SENP5-8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp564O1016; FLJ42398; MGC27076; Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5; Smt3ip3; SUMO/sentrin specific protease 5; SUMO/Smt3-specific isopeptidase 3; SUMO1/sentrin specific peptidase 5; SUMO1/sentrin specific protease 5; Sumo1/sentrin/SMT3 specific peptidase 5
Gene Aliases: 6230429P13Rik; A730063F07Rik; AI851888; BB189556; FKSG45; SENP5; SMT3IP3
Molecular Function: protease