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Product Details
PA5-63520
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SEPN1. Recombinant protein control fragment (Product #RP-99821).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2647121
Product Specific Information
Immunogen sequence: WSLVKELEEL QNKQENSSHQ KLAGLHLEKY SFPVEMMICL PNGTVVHHIN ANYFLDITSV KPEEIESNLF SFSSTFEDPS T
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 80%.
Target Information
SEPN1 is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. Mutations in SEPN1 gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Mutations in this gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ24021; Selenoprotein N; SelN
Gene Aliases: CFTD; MDRS1; RSMD1; RSS; SELENON; SELN; SEPN1
UniProt ID: (Human) Q9NZV5
Entrez Gene ID: (Human) 57190
respiratory system process
mitochondrion organization
biological_process
skeletal muscle satellite cell differentiation
positive regulation of skeletal muscle cell proliferation
response to muscle activity involved in regulation of muscle adaptation
multicellular organismal response to stress
cellular response to oxidative stress
skeletal muscle tissue regeneration
lung alveolus development
skeletal muscle fiber development
calcium ion homeostasis
oxidation-reduction process
regulation of ryanodine-sensitive calcium-release channel activity
cellular response to caffeine
positive regulation of response to oxidative stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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