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Product Details
11631-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
Immunocytochemistry (ICC/IF) |
- | View 1 publication 1 publication |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
SEPT5 Fusion Protein Ag2205 (1-369 aa encoded by BC025261) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.2 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: MSTGLRYKS KLATPEDKQD IDKQYVGFAT LPNQVHRKSV KKGFDFTLMV AGESGLGKST LVHSLFLTDL YKDRKLLSAE ERISQTVEIL KHTVDIEEKG VKLKLTIVDT PGFGDAVNNT ECWKPITDYV DQQFEQYFRD ESGLNRKNIQ DNRVHCCLYF ISPFGHGLRP VDVGFMKALH EKVNIVPLIA KADCLVPSEI RKLKERIREE IDKFGIHVYQ FPECDSDEDE DFKQQDRELK ESAPFAVIGS NTVVEAKGQR VRGRLYPWGI VEVENQAHCD FVKLRNMLIR THMHDLKDVT CDVHYENYRA HCIQQMTSKL TQDSRMESPI PILPLPTPDA ETEKLIRMKD EELRRMQEML QRMKQQMQDQ (1-369 aa encoded by BC025261)
Target Information
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Two transcripts of this gene, a major one of 2.2 kb and a minor one of 3.5 kb, have been observed. The 2.2 kb form results from the utilization of a non-consensus polyA signal (AACAAT). In the absence of polyadenylation from this imperfect site, the consensus polyA signal of the downstream neighboring gene (GP1BB; platelet glycoprotein Ib) is used, resulting in the 3.5 kb transcript. An alternatively spliced transcript variant with a different 5' end has also been identified, but its full-length nature has not been completely determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CDCrel-1; cell division control related protein 1; Cell division control-related protein 1; peanut-like 1; peanut-like 1 homolog; Peanut-like protein 1; platelet glycoprotein Ib beta chain; Septin-5
Gene Aliases: 5-Sep; CDCREL; CDCREL-1; CDCrel-1A; CDCREL1; H5; HCDCREL-1; PNUTL1; SEPT5; SEPTIN5
UniProt ID: (Human) Q99719, (Mouse) Q9Z2Q6
Entrez Gene ID: (Human) 5413, (Mouse) 18951, (Rat) 116728
Molecular Function:
cytoskeletal protein
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