This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression.
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Protein Aliases: 7-Sep; CDC10 (cell division cycle 10, S. cerevisiae, homolog); CDC10 (cell division cycle 10, S.cerevisiae, homolog); CDC10 protein homolog; cell division cycle 10 homolog; septin 7 variant 4; Septin-7
Gene Aliases: CDC10; CDC3; E430034N22; NBLA02942; SEPT7; SEPT7A; SEPTIN7