Keep as concentrated solution.
Predicted reactivity: Rhesus Monkey (86%).
Positive Control: U87-MG, SK-N-SH, IMR32, SK-N-AS, human SERPIN-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
SERPINA encodes Alpha 1-ACT. It is an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. Alpha-1-ACT, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimer's disease (AD) and in normal aged human and monkey brain. Regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation. Prostate specific antigen (PSA), a chymotrypsin-like serine protease, is predominantly complexed to Alpha-1-ACT.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
Protein Aliases: ACT; Alpha-1-antichymotrypsin; Alpha-1-antichymotrypsin His-Pro-less; Cell growth-inhibiting gene 24/25 protein; growth-inhibiting protein 24; growth-inhibiting protein 25; MGC88254; serine (or cysteine) proteinase inhibitor, clade A, member 3; Serpin A3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Gene Aliases: AACT; ACT; GIG24; GIG25; SERPINA3
UniProt ID: (Human) Q2TU87
Entrez Gene ID: (Human) 12
Molecular Function: protease inhibitor