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FIGURE: 1 / 3
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Acrosomal serine protease inhibitor; alpha-1 antiproteinase; antitr; antitrypsin; PAI-3; PAI3; PCI; Plasma serine protease inhibitor; Plasminogen activator inhibitor 3; plasminogen activator inhibitor III; plasminogen activator inhibitor-3; Protein C inhibitor; serine (or cysteine) peptidase inhibitor, clade A, member 5; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5; serine (or cysteine) proteinase inhibitor, clade A, member 5; Serpin A5; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5; serpin peptidase inhibitor, clade A, member 5
Gene Aliases: 4933415L04; PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI; SERPINA5
UniProt ID: (Human) P05154, (Mouse) P70458
Entrez Gene ID: (Human) 5104, (Mouse) 268591, (Rat) 65051
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