Recommended positive controls: NCI-H929.
Predicted reactivity: Rabbit (81%), Bovine (81%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein that is predominantly expressed in mesangial cells, which play an important role in maintaining glomerular structure and function. As a member of the serpin family, megsin is a serine protesase inhibitor which potentially inactivate MMP-2, MMP-9 and plasmin, proteins that are notably responsible for degradation of extracellular matrix. Overexpression of megsin results in an increase in number of mesangial cells and therefore a progressive mesangial matrix expansion, which is accompanied by immune complex deposition. This finding suggests that megsin significantly influences the role of mesangial cells in renal structure and is likely implicated in a variety of nephropathies.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
Protein Aliases: Megsin; mesangium predominant gene, megsin; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7; Serpin B7; serpin peptidase inhibitor, clade B (ovalbumin), member 7; Serpin-B7; TP55
Gene Aliases: MEGSIN; PPKN; SERPINB7; TP55
UniProt ID: (Human) O75635
Entrez Gene ID: (Human) 8710