The superfamily of high molecular weight serine proteinase inhibitors. A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position.
Protein Aliases: CAP-2; Cytoplasmic antiproteinase 2; Peptidase inhibitor 8; PI-8; protease inhibitor 8 (ovalbumin type); serine (or cysteine) peptdiase inhibitor, clade B, member 8; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8; serine (or cysteine) proteinase inhibitor, clade B, member 8; serine protease inhibitor 8; Serpin B8; serpin peptidase inhibitor, clade B (ovalbumin), member 8
Gene Aliases: CAP-2; CAP2; NK10; ovalbumin; PI8; SERPINB8; Spi8
Molecular Function: protease inhibitor