This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants.
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Protein Aliases: GDN; Glia derived nexin; Glia-derived nexin; glial-derived neurite promoting factor; Peptidase inhibitor 7; PI 7; PI-7; PN 1; PN-1; PNI; Protease nexin 1; Protease nexin I; Serpin E2; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; SERPINE2
Gene Aliases: GDN; GDNPF; PI-7; PI7; PN-1; PN1; PNI; SERPINE2
UniProt ID: (Human) P07093
Entrez Gene ID: (Human) 5270