SERPINE2 encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants.
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Protein Aliases: GDN; GDNPF; Glia-derived nexin; glial-derived neurite promoting factor; Peptidase inhibitor 7; PI-7; PN-1; PNI; Protease nexin 1; Protease nexin I; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine protease inhibitor 4; Serine protease-inhibitor 4; Serpin E2; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Gene Aliases: B230326M24Rik; GDN; GDNPF; PAI-1; PI-7; PI7; PN-1; PN1; PNI; SERPINE2; Spi4