Immunogen sequence: SPPALLPEKD SFSSALDEIE ELCPTSTSTE AATAATDSVK GTSSEAGTQK LDGPQESRAD DSKLMDSLPG NFEITTSTGF LTDLTLDDIL FADIDTSMYD FDPCTSSSGT ASKMAPVSAD DLLKTLAP
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 85%.
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. [UniProt]
Protein Aliases: MGC126688; MGC126690; SERTA domain-containing protein 2; Transcriptional regulator interacting with the PHD-bromodomain 2; transcriptional regulator interacting with the PHS-bromodomain 2; TRIP-Br2
Gene Aliases: KIAA0127; Sei-2; SERTAD2; TRIP-Br2; TRIPBR2
UniProt ID: (Human) Q14140
Entrez Gene ID: (Human) 9792
Molecular Function: transcription cofactor