Proteintech

SESN1 Polyclonal Antibody

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SESN1 Antibody (21668-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 21668-1-AP) SESN1 antibody at dilution of 1:2,000 incubated at room temperature for 1.5 hours.

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Product Details

21668-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SESN1 Fusion Protein Ag16462 (1-141 aa encoded by BC112036)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAEGENEVR WDGLCSRDST TRETALENIR QTILRKTEYL RSVKETPHRP SDGLSNTESS DGLNKLLAHL LMLSKRCPFK DVREKSEFIL KSIQELGIRI PRPLGQGPSR FIPEKEILQV GSEDAQMHAL FADSFAALGR LD (1-141 aa encoded by BC112036)

Target Information

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Ring domains are essential for GATOR2-dependent mTORC1 activation.

Molecular cell

Jiang C,Dai X,He S,Zhou H,Fang L,Guo J,Liu S,Zhang T,Pan W,Yu H,Fu T,Li D,Inuzuka H,Wang P,Xiao J,Wei W

Thu Jan 05 00:00:00 UTC 2023

Exercise ameliorates chronic inflammatory response induced by high-fat diet via Sestrin2 in an Nrf2-dependent manner.

Biochimica et biophysica acta. Molecular basis of disease

Liu S,Li H,Zhang Y,Song H,Fu L

Sun Oct 01 00:00:00 UTC 2023

Effects of Leucine Ingestion and Contraction on the Sestrin/GATOR2 Pathway and mTORC1 Activation in Rat Fast-Twitch muscle.

The Journal of nutrition

Kanzaki K,Wada M

Tue Aug 01 00:00:00 UTC 2023

Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.

Science (New York, N.Y.)

Cangelosi AL,Puszynska AM,Roberts JM,Armani A,Nguyen TP,Spinelli JB,Kunchok T,Wang B,Chan SH,Lewis CA,Comb WC,Bell GW,Helman A,Sabatini DM

Fri Jul 01 00:00:00 UTC 2022

SAR1B senses leucine levels to regulate mTORC1 signalling.

Nature

Chen J,Ou Y,Luo R,Wang J,Wang D,Guan J,Li Y,Xia P,Chen PR,Liu Y

Sun Aug 01 00:00:00 UTC 2021

Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

Wang T,Hu W,Niu Y,Liu S,Fu L

Mon Nov 01 00:00:00 UTC 2021

Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.

BMC cancer

Jang SK,Hong SE,Lee DH,Kim JY,Kim JY,Ye SK,Hong J,Park IC,Jin HO

Mon Jul 12 00:00:00 UTC 2021

Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.

BioMed research international

Du J,He W,Zhang C,Wu J,Li Z,Wang M,Feng S,Liang G

Mon Nov 23 00:00:00 UTC 2020

Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle.

American journal of physiology. Endocrinology and metabolism

Xu D,Shimkus KL,Lacko HA,Kutzler L,Jefferson LS,Kimball SR

Wed May 01 00:00:00 UTC 2019

Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.

Biochimica et biophysica acta. Molecular basis of disease

Wang T,Niu Y,Liu S,Yuan H,Liu X,Fu L

Mon Oct 01 00:00:00 UTC 2018

Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.

Biochimica et biophysica acta. Molecular basis of disease

Wang T,Niu Y,Liu S,Yuan H,Liu X,Fu L

Mon Oct 01 00:00:00 UTC 2018

Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb.

Physiological reports

Shimkus KL,Jefferson LS,Gordon BS,Kimball SR

Mon Oct 01 00:00:00 UTC 2018

Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb.

Physiological reports

Shimkus KL,Jefferson LS,Gordon BS,Kimball SR

Mon Oct 01 00:00:00 UTC 2018

Defective interplay between mTORC1 activity and endoplasmic reticulum stress-unfolded protein response in uremic vascular calcification.

American journal of physiology. Renal physiology

Panda DK,Bai X,Sabbagh Y,Zhang Y,Zaun HC,Karellis A,Koromilas AE,Lipman ML,Karaplis AC

Fri Jun 01 00:00:00 UTC 2018

Sestrin-Mediated Inhibition of Stress-Induced Intervertebral Disc Degradation Through the Enhancement of Autophagy.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Tu J,Li W,Li S,Liu W,Zhang Y,Wu X,Luo R,Hua W,Wang K,Song Y,Kang L,Yang W,Yang S,Yang C

Mon May 14 00:00:00 UTC 2018

Sestrin-Mediated Inhibition of Stress-Induced Intervertebral Disc Degradation Through the Enhancement of Autophagy.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Tu J,Li W,Li S,Liu W,Zhang Y,Wu X,Luo R,Hua W,Wang K,Song Y,Kang L,Yang W,Yang S,Yang C

Mon May 14 00:00:00 UTC 2018

Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.

Osteoarthritis and cartilage

Shen T,Alvarez-Garcia O,Li Y,Olmer M,Lotz MK

Wed Feb 01 00:00:00 UTC 2017

Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.

Osteoarthritis and cartilage

Shen T,Alvarez-Garcia O,Li Y,Olmer M,Lotz MK

Wed Feb 01 00:00:00 UTC 2017

Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.

Diabetes

Tao R,Xiong X,Liangpunsakul S,Dong XC

Wed Apr 01 00:00:00 UTC 2015

Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.

Diabetes

Tao R,Xiong X,Liangpunsakul S,Dong XC

Wed Apr 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: p53 activated gene 26; p53 regulated PA26 nuclear protein; p53-regulated protein PA26; Sestrin-1

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Gene Aliases: 1110002G11Rik; AU044290; PA26; SESN1; SEST1

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UniProt ID: (Human) Q9Y6P5, (Mouse) P58006

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Entrez Gene ID: (Human) 27244, (Mouse) 140742, (Rat) 294518

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Function(s)

protein binding peroxiredoxin activity leucine binding molecular_function peroxidase

Process(es)

oxidation-reduction process cellular response to amino acid stimulus reactive oxygen species metabolic process cellular oxidant detoxification regulation of response to reactive oxygen species negative regulation of TORC1 signaling regulation of protein kinase B signaling

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SESN1 Polyclonal Antibody

SESN1 Antibody (21668-1-AP) in WB

Product Details

21668-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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