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Abnova
SESN1 Polyclonal Antibody, MaxPab™
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Product Details
H00027244-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SESN1 (NP_055269.1, 1 a.a. approximately 551 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MAEGENEVRW DGLCSRDSTT RETALENIRQ TILRKTEYLR SVKETPHRPS DGLSNTESSD GLNKLLAHLL MLSKRCPFKD VREKSEFILK SIQELGIRIP RPLGQGPSRF IPEKEILQVG SEDAQMHALF ADSFAALGRL DNITLVMVFH PQYLESFLKT QHYLLQMDGP LPLHYRHYIG IMAAARHQCS YLVNLHVNDF LHVGGDPKWL NGLENAPQKL QNLGELNKVL AHRPWLITKE HIEGLLKAEE HSWSLAELVH AVVLLTHYHS LASFTFGCGI SPEIHCDGGH TFRPPSVSNY CICDITNGNH SVDEMPVNSA ENVSVSDSFF EVEALMEKMR QLQECRDEEE ASQEEMASRF EIEKRESMFV FSSDDEEVTP ARAVSRHFED TSYGYKDFSR HGMHVPTFRV QDYCWEDHGY SLVNRLYPDV GQLIDEKFHI AYNLTYNTMA MHKDVDTSML RRAIWNYIHC MFGIRYDDYD YGEINQLLDR SFKVYIKTVV CTPEKVTKRM YDSFWRQFKH SEKVHVNLLL IEARMQAELL YALRAITRYM T
Target Information
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p53 activated gene 26; p53 regulated PA26 nuclear protein; p53-regulated protein PA26; Sestrin-1
Gene Aliases: PA26; SESN1; SEST1
UniProt ID: (Human) Q9Y6P5
Entrez Gene ID: (Human) 27244
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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