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SESN3 Polyclonal Antibody

FIGURE: 1 / 13

SESN3 Antibody (11431-2-AP) in WB

Mouse liver tissue were subjected to SDS PAGE followed by western blot with 11431-2-AP (SESN3 antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours.

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Product Details

11431-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SESN3 Fusion Protein Ag1961 (1-321 aa encoded by BC017296)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MNRGGGSPS AAANYLLCTN CRKVLRKDKR IRVSQPLTRG PSAFIPEKEV VQANTVDERT NFLVEEYSTS GRLDNITQVM SLHTQYLESF LRSQFYMLRM DGPLPLPYRH YIAIMAAARH QCSYLINMHV DEFLKTGGIA EWLNGLEYVP QRLKNLNEIN KLLAHRPWLI TKEHIQKLVK TGENNWSLPE LVHAVVLLAH YHALASFVFG SGINPERDPE ISNGFRLISV NNFCVCDLAN DNNIENASLS GSNFGIVDSL SELEALMERM KRLQEEREDE EASQEEMSTR FEKEKKESLF VVSGDTFHSF PHSGAFLHFF AF (1-321 aa encoded by BC017296)

Target Information

May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Exercise ameliorates chronic inflammatory response induced by high-fat diet via Sestrin2 in an Nrf2-dependent manner.

Biochimica et biophysica acta. Molecular basis of disease

Liu S,Li H,Zhang Y,Song H,Fu L

Sun Oct 01 00:00:00 UTC 2023

Inhibition of p21 activates Akt kinase to trigger ROS-induced autophagy and impacts on tumor growth rate.

Cell death & disease

Maheshwari M,Yadav N,Hasanain M,Pandey P,Sahai R,Choyal K,Singh A,Nengroo MA,Saini KK,Kumar D,Mitra K,Datta D,Sarkar J

Thu Dec 15 00:00:00 UTC 2022

Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

Wang T,Hu W,Niu Y,Liu S,Fu L

Mon Nov 01 00:00:00 UTC 2021

Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.

BMC cancer

Jang SK,Hong SE,Lee DH,Kim JY,Kim JY,Ye SK,Hong J,Park IC,Jin HO

Mon Jul 12 00:00:00 UTC 2021

FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.

Proceedings of the National Academy of Sciences of the United States of America

Lee KI,Choi S,Matsuzaki T,Alvarez-Garcia O,Olmer M,Grogan SP,D'Lima DD,Lotz MK

Tue Feb 11 00:00:00 UTC 2020

Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.

Biochimica et biophysica acta. Molecular basis of disease

Wang T,Niu Y,Liu S,Yuan H,Liu X,Fu L

Mon Oct 01 00:00:00 UTC 2018

Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.

Biochimica et biophysica acta. Molecular basis of disease

Wang T,Niu Y,Liu S,Yuan H,Liu X,Fu L

Mon Oct 01 00:00:00 UTC 2018

Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.

Brain research

Huang LG,Zou J,Lu QC

Fri Jun 15 00:00:00 UTC 2018

Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.

Brain research

Huang LG,Zou J,Lu QC

Fri Jun 15 00:00:00 UTC 2018

Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.

Brain research

Huang LG,Zou J,Lu QC

Fri Jun 15 00:00:00 UTC 2018

Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation.

eLife

Nogueira V,Patra KC,Hay N

Tue Apr 24 00:00:00 UTC 2018

Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation.

eLife

Nogueira V,Patra KC,Hay N

Tue Apr 24 00:00:00 UTC 2018

Sestrin-Mediated Inhibition of Stress-Induced Intervertebral Disc Degradation Through the Enhancement of Autophagy.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Tu J,Li W,Li S,Liu W,Zhang Y,Wu X,Luo R,Hua W,Wang K,Song Y,Kang L,Yang W,Yang S,Yang C

Mon May 14 00:00:00 UTC 2018

Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.

Osteoarthritis and cartilage

Shen T,Alvarez-Garcia O,Li Y,Olmer M,Lotz MK

Wed Feb 01 00:00:00 UTC 2017

Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.

Osteoarthritis and cartilage

Shen T,Alvarez-Garcia O,Li Y,Olmer M,Lotz MK

Wed Feb 01 00:00:00 UTC 2017

Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.

PloS one

Vakana E,Arslan AD,Szilard A,Altman JK,Platanias LC

Mon Jul 07 00:00:00 UTC 2014

Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.

PloS one

Vakana E,Arslan AD,Szilard A,Altman JK,Platanias LC

Mon Jul 07 00:00:00 UTC 2014

FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor.

Developmental cell

Chen CC,Jeon SM,Bhaskar PT,Nogueira V,Sundararajan D,Tonic I,Park Y,Hay N

Tue Apr 20 00:00:00 UTC 2010

FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor.

Developmental cell

Chen CC,Jeon SM,Bhaskar PT,Nogueira V,Sundararajan D,Tonic I,Park Y,Hay N

Tue Apr 20 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: Sestrin-3

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Gene Aliases: 5630400E15Rik; BC003348; SESN3; SEST3

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UniProt ID: (Human) P58005, (Mouse) Q9CYP7

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Entrez Gene ID: (Human) 143686, (Rat) 315427, (Mouse) 75747

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Function(s)

oxidoreductase activity molecular_function peroxidase

Process(es)

oxidation-reduction process cellular response to amino acid stimulus regulation of response to reactive oxygen species negative regulation of TORC1 signaling response to insulin glucose homeostasis regulation of protein kinase B signaling

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SESN3 Polyclonal Antibody

SESN3 Antibody (11431-2-AP) in WB

Product Details

11431-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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