FIGURE: 1 / 3
Recommended positive controls: HeLa, Raw264.7, C2C12, Rat2.
Predicted reactivity: Mouse (94%), Rat (93%), Xenopus laevis (80%), Rhesus Monkey (98%), Chimpanzee (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Sestrin-3
Gene Aliases: 5630400E15Rik; BC003348; SESN3; SEST3
Molecular Function: peroxidase