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Invitrogen
SESN3 Polyclonal Antibody
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Product Details
PA5-22220
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human SESN3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.36 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HeLa, Raw264.7, C2C12, Rat2.
Predicted reactivity: Mouse (94%), Rat (93%), Xenopus laevis (80%), Rhesus Monkey (98%), Chimpanzee (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Sestrin-3
Gene Aliases: 5630400E15Rik; BC003348; SESN3; SEST3
UniProt ID: (Human) P58005, (Mouse) Q9CYP7
Entrez Gene ID: (Human) 143686, (Rat) 315427, (Mouse) 75747
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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