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Invitrogen
SETD2 Polyclonal Antibody
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Product Details
PA5-102710
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SETD2(Accession Q9BYW2), corresponding to amino acid residues R507-S557.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SETD2.
Target Information
Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis. Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ16420; FLJ22472; FLJ23184; FLJ45883; HIF-1; HIP-1; Histone-lysine N-methyltransferase SETD2; hSET2; huntingtin interacting protein 1; Huntingtin yeast partner B; Huntingtin-interacting protein 1; Huntingtin-interacting protein B; kinesin family member 9; Lysine N-methyltransferase 3A; p231HBP; Protein-lysine N-methyltransferase SETD2; SET domain-containing protein 2
Gene Aliases: 4921524K10Rik; BC031601; HBP231; HIF-1; HIF1; HIP-1; HSPC069; HYPB; KIAA1732; Kif9; KMT3A; LLS; p231HBP; SET2; SETD2
UniProt ID: (Human) Q9BYW2, (Mouse) E9Q5F9
Entrez Gene ID: (Human) 29072, (Rat) 316013, (Mouse) 235626
angiogenesis
morphogenesis of a branching structure
neural tube closure
mismatch repair
regulation of transcription, DNA-templated
transcription elongation from RNA polymerase II promoter
regulation of mRNA export from nucleus
forebrain development
nucleosome organization
cell migration involved in vasculogenesis
mesoderm morphogenesis
embryonic cranial skeleton morphogenesis
stem cell development
pericardium development
embryonic placenta morphogenesis
coronary vasculature morphogenesis
histone H3-K36 trimethylation
histone H3-K36 dimethylation
vasculogenesis
biological_process
histone H3-K36 methylation
regulation of gene expression
peptidyl-lysine trimethylation
embryonic organ development
transcription, DNA-templated
chromatin modification
methylation
histone lysine methylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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