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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 1193-1225 amino acids from the C-terminal region of human SETDB1|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with mouse and Xenopus and zebrafish based on sequence homology.
The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived. Studies have suggested that the SET domain may be a signature of proteins that modulate transcriptionally active or repressed chromatin states through chromatin remodeling activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ERG-associated protein with a SET domain, ESET; ERG-associated protein with SET domain; ESET; H3-K9-HMTase 4; histone H3-K9 methyltransferase 4; histone-lysine N-methyltransferase, H3lysine-9 specific 4; KMT1E; lysine N-methyltransferase 1E; SET domain, bifurcated 1; tudor domain containing 21
ESET; H3-K9-HMTase4; KG1T; KIAA0067; KMT1E; SETDB1; TDRD21