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Invitrogen
SETMAR Polyclonal Antibody
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Product Details
PA5149726
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SETMAR
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ELSYDYSGRY LNLTVSEDKE RLDHGKLRKP CYCGAKSCTA FLPFDSSLYC PVEKSNISCG NEKEPSMCGS APSVFPSCKR LTL
Highest antigen sequence identity to the following orthologs: Mouse - 42%, Rat - 47%.
Target Information
SETMAR (SET domain and mariner transposase fusion gene) is a histone methyltransferase that methylates Lys-4 and Lys-36 of histone H3, creating specific tags for epigenetic transcriptional activation. It specifically mediates dimethylation of H3 Lys-36. SETMAR has sequence-specific DNA-binding activity, and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 transposable element. SETMAT has DNA nicking activity, and in vivo end-joining activity, and may mediate genomic integration of foreign DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Histone-lysine N-methyltransferase SETMAR; methylase and endonuclease; Metnase; orf; encodes putative chimeric protein with SET domain in N-terminus with similarity to several other human, Drosophila, nematode and yeast proteins; SET domain and mariner transposase fusion gene-containing protein; SET domain and mariner transposase fusion protein; unnamed protein product
Gene Aliases: Mar1; METNASE; SETMAR
UniProt ID: (Human) Q53H47
Entrez Gene ID: (Human) 6419
single-stranded DNA endodeoxyribonuclease activity
nucleic acid binding
DNA binding
double-stranded DNA binding
single-stranded DNA binding
catalytic activity
nuclease activity
endonuclease activity
protein binding
methyltransferase activity
zinc ion binding
protein-lysine N-methyltransferase activity
transferase activity
hydrolase activity
histone methyltransferase activity
histone methyltransferase activity (H3-K4 specific)
protein homodimerization activity
DNA topoisomerase binding
metal ion binding
histone methyltransferase activity (H3-K36 specific)
histone H3 methyltransferase activity
histone H3K36 dimethyltransferase activity
DNA double-strand break processing
DNA repair
double-strand break repair via nonhomologous end joining
DNA catabolic process
chromatin organization
chromatin remodeling
cellular response to DNA damage stimulus
cell proliferation
DNA integration
replication fork processing
methylation
mitotic DNA integrity checkpoint
nucleic acid metabolic process
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
positive regulation of double-strand break repair via nonhomologous end joining
negative regulation of chromosome organization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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