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Proteintech
SF3A1 Polyclonal Antibody
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Product Details
15858-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SF3A1 Fusion Protein Ag8196 (443-793 aa encoded by BC007684)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DRSIREKQS DDEVYAPGLD IESSLKQLAE RRTDIFGVEE TAIGKKIGEE EIQKPEEKVT WDGHSGSMAR TQQAAQANIT LQEQIEAIHK AKGLVPEDDT KEKIGPSKPN EIPQQPPPPS SATNIPSSAP PITSVPRPPT MPPPVRTTVV SAVPVMPRPP MASVVRLPPG SVIAPMPPII HAPRINVVPM PPSAPPIMAP RPPPMIVPTA FVPAPPVAPV PAPAPMPPVH PPPPMEDEPT SKKLKTEDSL MPEEEFLRRN KGPVSIKVQV PNMQDKTEWK LNGQVLVFTL PLTDQVSVIK VKIHEATGMP AGKQKLQYEG IFIKDSNSLA YYNMANGAVI HLALKERGGR KK (443-793 aa encoded by BC007684)
Target Information
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: pre-mRNA processing 21; pre-mRNA splicing factor SF3a (120 kDa subunit); SAP 114; SF3A1; SF3a120; Spliceosome-associated protein 114; splicing factor 3 subunit 1; Splicing factor 3A subunit 1; splicing factor 3a, subunit 1, 120kD; splicing factor 3a, subunit 1, 120kDa; unnamed protein product
Gene Aliases: 1200014H24Rik; 5930416L09Rik; AI159724; PRP21; PRPF21; SAP114; SF3A1; SF3A120
UniProt ID: (Human) Q15459, (Mouse) Q8K4Z5
Entrez Gene ID: (Human) 10291, (Mouse) 67465, (Rat) 305479
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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