Immunogen sequence: SLESLDTSLF AKNPKSKGTK RDTERNKDIA FLEAQIYEYV EILGEQRHLT HENVQRKQAR TGEEREEEEE EQISESESED EENEIIYNPK NLPLGWDGKP IPYWLYKLHG LNINYNCEIC GNYTYRGPKA FQRHFAEWRH AHGMRCLGIP NTAHFANVTQ IEDAVSLWAK LKLQKASERW QPDTEEEYED SSGNVVNKKT YEDLKRQGLL; Positive Samples: B cells, A-549, HepG2, HeLa, HL-60, Mouse lung, Mouse thymus, Rat liver; Cellular Location: Nucleus speckle
This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20.
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Protein Aliases: pre-mRNA splicing factor SF3a (60kD); SAP 61; SF3a60; spliceosome associated protein 61; Spliceosome-associated protein 61; Splicing factor 3A subunit 3; splicing factor 3a, subunit 3, 60kD; splicing factor 3a, subunit 3, 60kDa
Gene Aliases: 4930512K19Rik; 60kDa; LRRGT00093; PRP9; PRPF9; SAP61; SF3A3; SF3a60
Molecular Function: RNA splicing factor