This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex. The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Protein Aliases: pre-mRNA processing 10; pre-mRNA splicing factor SF3b, 155 kDa subunit; Pre-mRNA-splicing factor SF3b 155 kDa subunit; SAP 155; SF3b155; Spliceosome-associated protein 155; Splicing factor 3B subunit 1; splicing factor 3b, subunit 1, 155 kDa; splicing factor 3b, subunit 1, 155kD; splicing factor 3b, subunit 1, 155kDa; transforming growth factor alpha regulated gene 4
Gene Aliases: 155kDa; 2810001M05Rik; AA409119; Hsh155; MDS; PRP10; PRPF10; SAP155; SF3B1; SF3b155; TA-8; Targ4
UniProt ID: (Human) O75533