This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated. View Details
This antibody is predicted to react with mouse and Xenopus laevis based on sequence homology.
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex . The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Protein Aliases: Hsh155, PRP10, PRPF10, SAP155, SF3b155, SAP 155; pre-mRNA processing 10; pre-mRNA splicing factor SF3b, 155 kDa subunit; Pre-mRNA-splicing factor SF3b 155 kDa subunit; SAP 155; SF3b155; spliceosome associated protein 155; Spliceosome-associated protein 155; Splicing factor 3B subunit 1; splicing factor 3b, subunit 1, 155 kDa; splicing factor 3b, subunit 1, 155kDa; transforming growth factor alpha regulated gene 4
Gene Aliases: 155kDa; 2810001M05Rik; AA409119; Hsh155; MDS; PRP10; PRPF10; SAP155; SF3B1; SF3b155; TA-8; Targ4
UniProt ID: (Human) O75533