This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
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Protein Aliases: frizzled-related protein; FRP; FRP 1; FRP-1; FRP1; FrzA; SARP 2; SARP-2; SARP2; Secreted apoptosis-related protein 2; Secreted frizzled-related protein 1; secreted frizzled-related sequence protein 1; sFRP 1; sFRP-1; SFRP1
Gene Aliases: 2210415K03Rik; AW011917; AW107218; AW742929; FRP; FRP-1; FRP1; FrzA; SARP2; sFRP-1; SFRP1